CHRM3

Across TCGA patient cohorts, CHRM3 protein abundance is significantly associated with the RNA expression of many other genes, with 15,571 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CHRM3-associated genes across cancer lineages are ALDH8A1, EQTN, and SOX21. Each is linked with CHRM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRM3-to-partner and partner-to-CHRM3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHRM3 versus ALDH8A1 in PDAC, with a Pearson correlation of 0.76.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRM3→partner) and Y-score (partner→CHRM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ALDH8A1 →	+0.675	+1.670	.004	.001	3	2
PDAC	EQTN →	+0.672	+1.580	.003	<.001	3	1
PDAC	SOX21 →	-1.682	-1.231	.008	.003	3	1
PDAC	DDX60 →	+0.632	+1.190	.008	.005	3	1
PDAC	NAPRT →	+1.084	+1.274	.005	.006	3	1
PDAC	ALPP →	+2.376	+1.109	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,571 associations by consensus.

CHRM3 vs ALDH8A1 — PDAC

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