CHRM3

Across TCGA patient cohorts, CHRM3 mutation is significantly associated with the RNA expression of many other genes, with 5,670 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRM3-associated genes across cancer lineages are KIF15, CDC7, and PSRC1. Each is linked with CHRM3 in more than 4 cancer types. Because this analysis shows association rather than direction, both CHRM3-to-partner and partner-to-CHRM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF15 grouped by CHRM3-low versus CHRM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRM3→partner) and Y-score (partner→CHRM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KIF15 →	+0.837	+4.119	<.001	<.001	3	5
UCEC	CDC7 →	+0.861	+3.711	<.001	<.001	3	5
UCEC	PSRC1 →	+0.762	+1.949	<.001	.001	3	5
LUAD	TROAP →	+0.818	+2.321	.006	.006	3	4
UCEC	KIF11 →	+0.966	+2.305	<.001	<.001	3	4
UCEC	ZNF367 →	+1.063	+3.115	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,670 associations by consensus.

KIF15 by CHRM3 expression — UCEC

Explore this box plot interactively →