CHRM3

Across TCGA cell cohorts, CHRM3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,742 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CHRM3-associated GO terms across cancer lineages are Saliva secretion, Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway, and G protein-coupled acetylcholine receptor signaling pathway. Each is linked with CHRM3 in more than 17 cancer types. Because this analysis shows association rather than direction, both CHRM3-to-partner and partner-to-CHRM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Saliva secretion grouped by CHRM3-low versus CHRM3-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRM3→partner) and Y-score (partner→CHRM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Saliva secretion →	+1.270	+2.706	<.001	<.001	3	18
BLOOD_Myeloma	Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway →	+1.402	+1.651	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	G protein-coupled acetylcholine receptor signaling pathway →	-0.239	-1.381	<.001	<.001	3	10
SOFT_TISSUE	Regulation of DNA-templated transcription elongation →	+0.064	+1.014	<.001	.003	3	8
SKIN	Regulation of myoblast fusion →	+0.082	+0.925	<.001	.006	3	8
LUNG_NSCLC_LUSC	Regulation of syncytium formation by plasma membrane fusion →	+0.089	+2.442	.001	.006	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,742 associations by consensus.

Saliva secretion by CHRM3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →