CHRM3

Across TCGA cell cohorts, CHRM3 mutation is significantly associated with the RNA expression of many other genes, with 248 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHRM3-associated genes across cancer lineages are S100G, EN1, and PEBP4. Each is linked with CHRM3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHRM3-to-partner and partner-to-CHRM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S100G grouped by CHRM3-low versus CHRM3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRM3→partner) and Y-score (partner→CHRM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	S100G →	+0.746	+2.425	.003	.004	3	3
LARGE_INTESTINE	EN1 →	+0.931	+2.758	<.001	.003	3	2
LUNG_SCLC	PEBP4 →	+0.025	+2.616	.003	.005	3	1
LUNG_SCLC	MUC17 →	+0.006	+2.616	<.001	.005	3	1
LUNG_SCLC	ASCL3 →	+0.191	+3.334	.006	.006	3	1
LUNG_SCLC	CLEC2A →	+0.047	+3.029	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 248 associations by consensus.

S100G by CHRM3 expression — LARGE_INTESTINE

Explore this box plot interactively →