CHRM2

Across TCGA pan-cancer cohorts, CHRM2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CHRM2 data layer compared with 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CHRM2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CHRM2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, SKCM, and KICH are the cancer types where CHRM2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.954	0.889	.001	76	view →
SKCM	OS	Median	II,III,IV	0.835	0.671	.003	60	view →
KICH	OS	Tertile	II,III,IV	0.155	0.880	<.001	42	view →
UVM	DFS	Tertile	All	0.438	0.809	.013	36	view →
LUAD	DFS	Median	IV	0.406	0.817	.007	36	view →
HNSC	DFS	Tertile	III,IV	0.324	0.581	.002	36	view →
LGG	DFS	Tertile	All	0.893	0.777	<.001	31	view →
CHOL	OS	Tertile	II,III,IV	0.019	0.765	.001	27	view →
BLCA	DFS	Median	All	0.566	0.681	.007	26	view →
KIRC	OS	Median	All	0.555	0.668	.004	25	view →
KIRP	OS	Quartile	II,III,IV	0.592	0.868	.036	16	view →
MESO	OS	Median	II,III,IV	0.479	0.633	.016	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CHRM2–UCEC (OS)

Open the UCEC breakdown →