CHRM1

Across TCGA cell cohorts, CHRM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,838 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible CHRM1-associated GO terms across cancer lineages are Heterochromatin organization, Positive regulation of ERK1 and ERK2 cascade, and Zymogen activation. Each is linked with CHRM1 in more than 4 cancer types. Because this analysis shows association rather than direction, both CHRM1-to-partner and partner-to-CHRM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heterochromatin organization grouped by CHRM1-low versus CHRM1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRM1→partner) and Y-score (partner→CHRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Heterochromatin organization →	+0.051	+0.063	.003	.002	3	5
LARGE_INTESTINE	Positive regulation of ERK1 and ERK2 cascade →	-0.038	-0.347	.001	.006	3	5
BREAST	Zymogen activation →	-0.178	-1.048	<.001	<.001	3	5
BREAST	Fibrinolysis →	-1.736	-1.574	<.001	<.001	3	5
BONE	Negative regulation of vascular permeability →	-0.158	-0.231	.003	.001	3	5
SKIN	Positive regulation of developmental growth →	-0.060	-0.778	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,838 associations by consensus.

Heterochromatin organization by CHRM1 expression — OVARY

Explore this box plot interactively →