CHRM1

Across TCGA cell cohorts, CHRM1 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CHRM1-associated genes across cancer lineages are TBL1Y, GAGE12E, and OR1L3. Each is linked with CHRM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRM1-to-partner and partner-to-CHRM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBL1Y grouped by CHRM1-low versus CHRM1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRM1→partner) and Y-score (partner→CHRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TBL1Y →	+0.053	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	GAGE12E →	+0.076	+4.643	<.001	.008	3	1
SKIN	OR1L3 →	+0.022	+4.415	<.001	.007	3	1
BLOOD_Leukemia	VSX2 →	+0.021	+3.258	.004	.007	3	1
BLOOD_Leukemia	LYZL2 →	+0.014	+4.247	<.001	.004	3	1
BLOOD_Leukemia	CALHM4 →	+0.020	+3.269	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

TBL1Y by CHRM1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →