CHRDL1

Across TCGA patient cohorts, CHRDL1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHRDL1-associated genes across cancer lineages are 4E-BP1, Annexin-1, and Cyclin-B1. Each is linked with CHRDL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHRDL1-to-partner and partner-to-CHRDL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by CHRDL1-low versus CHRDL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRDL1→partner) and Y-score (partner→CHRDL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.361	+1.938	<.001	.001	3	3
UCEC	Annexin-1 →	+0.413	+1.584	.017	.032	3	2
UCEC	Cyclin-B1 →	+0.562	+2.087	.002	.005	3	2
UCEC	14-3-3_beta →	-0.078	-2.295	.019	.005	3	1
UCEC	Fibronectin →	-0.279	-1.938	.010	.001	3	1
UCEC	Heregulin →	-0.095	-2.102	.019	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

4E-BP1 by CHRDL1 expression — UCEC

Explore this box plot interactively →