CHRDL1

Across TCGA cell cohorts, CHRDL1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CHRDL1-associated genes across cancer lineages are PSKH2, GAGE12D, and GAGE12C. Each is linked with CHRDL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHRDL1-to-partner and partner-to-CHRDL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSKH2 grouped by CHRDL1-low versus CHRDL1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHRDL1→partner) and Y-score (partner→CHRDL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PSKH2 →	+0.028	+4.887	<.001	.009	3	1
BLOOD_Lymphoma	GAGE12D →	+0.462	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	GAGE12C →	+0.462	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	TP53TG3E →	+0.035	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	FAM240A →	+0.016	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

PSKH2 by CHRDL1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →