CHPT1

Across TCGA pan-cancer cohorts, CHPT1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of CHPT1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CHPT1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CHPT1 is over-expressed in tumor, although a few such as LUAD and CCRCC show the opposite, repressed pattern.

LUAD, CCRCC, and LSCC are the cancer types where CHPT1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHPT1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	−0.238	<.001	5	view →
CCRCC	All	All	−0.213	<.001	4	view →
LSCC	All	All	−0.179	.005	4	view →
PDAC	All	III,IV	+1.162	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

CHPT1–LUAD

Open the LUAD breakdown →