CHPF2

Across TCGA patient cohorts, CHPF2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHPF2-associated genes across cancer lineages are eIF4E, PCNA, and PDCD4. Each is linked with CHPF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHPF2-to-partner and partner-to-CHPF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CHPF2-low versus CHPF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHPF2→partner) and Y-score (partner→CHPF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.209	+2.392	.004	<.001	3	2
UCEC	PCNA →	+0.256	+2.000	<.001	.003	3	2
UCEC	PDCD4 →	-0.537	-2.584	.001	.010	3	2
UCEC	ATM →	-0.606	-2.794	<.001	.002	3	2
UCEC	Caspase-8 →	-0.212	-2.089	.017	.016	3	2
UCEC	EGFR_pY1068 →	-0.229	-2.115	.009	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

eIF4E by CHPF2 expression — UCEC

Explore this box plot interactively →