CHP2

Across TCGA patient cohorts, CHP2 mutation is significantly associated with the RNA expression of many other genes, with 1,495 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHP2-associated genes across cancer lineages are RN7SL596P, PLAC8L1, and TMEM81. Each is linked with CHP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHP2-to-partner and partner-to-CHP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL596P grouped by CHP2-low versus CHP2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHP2→partner) and Y-score (partner→CHP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RN7SL596P →	+0.209	+4.628	<.001	.004	3	2
UCEC	PLAC8L1 →	+0.548	+2.243	.003	.006	3	2
UCEC	TMEM81 →	+0.453	+3.625	.002	.001	3	2
UCEC	RALA →	+0.532	+2.939	.001	<.001	3	2
UCEC	ACTB →	+0.445	+3.375	.005	.004	3	2
SKCM	GUSBP17 →	+0.123	+2.381	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,495 associations by consensus.

RN7SL596P by CHP2 expression — LUAD

Explore this box plot interactively →