CHP2

Across TCGA patient cohorts, CHP2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHP2-associated genes across cancer lineages are Notch1, A-Raf_pS299, and Heregulin. Each is linked with CHP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHP2-to-partner and partner-to-CHP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CHP2-low versus CHP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHP2→partner) and Y-score (partner→CHP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.226	+3.179	<.001	.010	3	2
UCEC	A-Raf_pS299 →	-0.171	-3.169	.001	.019	3	1
UCEC	Heregulin →	-0.129	-2.459	.020	.019	3	1
UCEC	Ku80 →	+0.253	+2.013	.017	.018	3	1
UCEC	MAPK_pT202_Y204 →	-0.611	-3.321	.003	.010	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.509	-3.169	.012	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Notch1 by CHP2 expression — UCEC

Explore this box plot interactively →