CHP2

Across TCGA cell cohorts, CHP2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHP2-associated genes across cancer lineages are FMO1, C1QTNF7, and DEFA4. Each is linked with CHP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHP2-to-partner and partner-to-CHP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FMO1 grouped by CHP2-low versus CHP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHP2→partner) and Y-score (partner→CHP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FMO1 →	+0.160	+3.777	<.001	.007	3	1
LARGE_INTESTINE	C1QTNF7 →	+0.096	+4.108	<.001	.008	3	1
LARGE_INTESTINE	DEFA4 →	+0.032	+4.437	<.001	.004	3	1
LARGE_INTESTINE	TBC1D21 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	ACSM6 →	+0.027	+4.169	<.001	.007	3	1
STOMACH	SPATA31D3 →	+0.013	+5.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

FMO1 by CHP2 expression — LARGE_INTESTINE

Explore this box plot interactively →