CHORDC1

Across TCGA patient cohorts, CHORDC1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHORDC1-associated genes across cancer lineages are MAPK_pT202_Y204, MEK1_p_S217_S221, and MSH2. Each is linked with CHORDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHORDC1-to-partner and partner-to-CHORDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK_pT202_Y204 grouped by CHORDC1-low versus CHORDC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHORDC1→partner) and Y-score (partner→CHORDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAPK_pT202_Y204 →	+0.610	+3.013	.002	.018	3	1
UCEC	MEK1_p_S217_S221 →	+0.364	+3.169	.002	.018	3	1
UCEC	MSH2 →	-0.335	-3.143	<.001	.018	3	1
UCEC	Caspase-7-cleavedD198 →	+0.961	+3.169	<.001	.018	3	1
UCEC	Chk1_pS345 →	+0.127	+2.128	.034	.010	3	1
UCEC	GSK3-a-b →	-0.167	-3.169	.004	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MAPK_pT202_Y204 by CHORDC1 expression — UCEC

Explore this box plot interactively →