CHN2

Across TCGA patient cohorts, CHN2 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHN2-associated genes across cancer lineages are ACVRL1, p62 Lck ligand, and Cyclin-B1. Each is linked with CHN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHN2-to-partner and partner-to-CHN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVRL1 grouped by CHN2-low versus CHN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHN2→partner) and Y-score (partner→CHN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACVRL1 →	-0.112	-1.787	.022	.026	3	2
UCEC	p62 Lck ligand →	+0.237	+1.925	.042	.005	3	2
UCEC	Cyclin-B1 →	+0.566	+2.321	.005	.034	3	2
UCEC	14-3-3_beta →	-0.114	-3.780	.001	<.001	3	1
UCEC	eIF4E →	+0.166	+3.013	.028	.018	3	1
UCEC	A-Raf_pS299 →	-0.134	-2.584	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

ACVRL1 by CHN2 expression — UCEC

Explore this box plot interactively →