CHMP7

Across TCGA pan-cancer cohorts, CHMP7 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of CHMP7’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CHMP7 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CHMP7 is over-expressed in tumor, although a few such as COAD and PDAC show the opposite, repressed pattern.

COAD, PDAC, and HNSC are the cancer types where CHMP7 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHMP7 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.183	<.001	9	view →
PDAC	Male	II,III,IV	−0.290	<.001	6	view →
HNSC	All	All	+0.081	.007	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

CHMP7–COAD

Open the COAD breakdown →