CHMP6

Across TCGA patient cohorts, CHMP6 protein abundance is significantly associated with the RNA expression of many other genes, with 5,860 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible CHMP6-associated genes across cancer lineages are MACROH2A1, CPA3, and DRP2. Each is linked with CHMP6 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHMP6-to-partner and partner-to-CHMP6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHMP6 versus MACROH2A1 in COAD, with a Pearson correlation of -0.26.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHMP6→partner) and Y-score (partner→CHMP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MACROH2A1 →	-0.331	-0.126	.003	.005	3	3
BRCA	CPA3 →	+1.748	+0.382	<.001	<.001	3	3
GBM	DRP2 →	+0.857	+0.229	.001	.002	3	3
OV	PDE10A →	+0.569	+0.389	<.001	.004	3	3
OV	CNRIP1 →	+0.865	+0.333	<.001	.001	3	3
GBM	DCLK1 →	+0.937	+0.226	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,860 associations by consensus.

CHMP6 vs MACROH2A1 — COAD

Explore this scatter interactively →