CHMP6

Across TCGA patient cohorts, CHMP6 mutation is significantly associated with the RNA expression of many other genes, with 150 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CHMP6-associated genes across cancer lineages are LLPHP1, TCERG1L-AS1, and MIR107. Each is linked with CHMP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHMP6-to-partner and partner-to-CHMP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LLPHP1 grouped by CHMP6-low versus CHMP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHMP6→partner) and Y-score (partner→CHMP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LLPHP1 →	+0.183	+3.814	<.001	.002	3	2
COAD	TCERG1L-AS1 →	+0.344	+4.542	<.001	.001	3	2
LIHC	MIR107 →	+0.426	+6.008	<.001	.002	3	2
CESC	RN7SL314P →	+0.101	+4.984	.008	.003	3	2
BLCA	USP9YP22 →	+0.204	+7.640	<.001	.009	3	2
LUSC	LACRT →	+0.418	+5.211	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 150 associations by consensus.

LLPHP1 by CHMP6 expression — UCEC

Explore this box plot interactively →