CHMP6

Across TCGA cell cohorts, CHMP6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,755 significant associations in total. CNS shows the largest number of these associations.

The most reproducible CHMP6-associated GO terms across cancer lineages are Midbody abscission, Regulation of anaphase-promoting complex-dependent catabolic process, and snRNA catabolic process. Each is linked with CHMP6 in more than 13 cancer types. Because this analysis shows association rather than direction, both CHMP6-to-partner and partner-to-CHMP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Midbody abscission grouped by CHMP6-low versus CHMP6-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHMP6→partner) and Y-score (partner→CHMP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Midbody abscission →	+0.082	+0.688	<.001	.005	3	14
BLOOD_Lymphoma	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.137	+0.882	<.001	<.001	3	11
OESOPHAGUS	snRNA catabolic process →	-0.139	-0.761	.001	<.001	3	11
BLOOD_Lymphoma	Late endosome to vacuole transport via multivesicular body sorting pathway →	+0.057	+0.795	<.001	<.001	3	10
BLOOD_Lymphoma	Mitotic cytokinetic process →	+0.073	+0.584	<.001	.001	3	10
SOFT_TISSUE	Non-lytic viral release →	+0.148	+0.850	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,755 associations by consensus.

Midbody abscission by CHMP6 expression — LUNG_SCLC

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