CHMP5

Across TCGA pan-cancer cohorts, CHMP5 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of CHMP5’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where CHMP5 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CHMP5 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

PDAC, COAD, and HNSC are the cancer types where CHMP5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHMP5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	All	II,III,IV	+0.431	<.001	7	view →
COAD	All	III,IV	−0.138	<.001	7	view →
HNSC	Male	All	−0.086	.031	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

CHMP5–PDAC

Open the PDAC breakdown →