CHMP5

Across TCGA patient cohorts, CHMP5 protein abundance is significantly associated with the RNA expression of many other genes, with 9,220 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CHMP5-associated genes across cancer lineages are TOPORS, SMU1, and B4GALT1-AS1. Each is linked with CHMP5 in more than 5 cancer types. Because this analysis shows association rather than direction, both CHMP5-to-partner and partner-to-CHMP5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHMP5 versus TOPORS in LSCC, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHMP5→partner) and Y-score (partner→CHMP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TOPORS →	+0.633	+0.236	<.001	<.001	3	6
LSCC	SMU1 →	+0.698	+0.249	<.001	<.001	3	6
COAD	B4GALT1-AS1 →	+0.391	+0.213	<.001	<.001	3	5
LSCC	APTX →	+0.586	+0.203	<.001	<.001	3	5
LSCC	NDUFB6 →	+0.617	+0.188	<.001	<.001	3	5
LSCC	NFX1 →	+0.651	+0.233	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,220 associations by consensus.

CHMP5 vs TOPORS — LSCC

Explore this scatter interactively →