CHMP5

Across TCGA patient cohorts, CHMP5 mutation is significantly associated with the RNA expression of many other genes, with 1,311 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHMP5-associated genes across cancer lineages are MRPS36P2, PWRN4, and TMPOP2. Each is linked with CHMP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHMP5-to-partner and partner-to-CHMP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS36P2 grouped by CHMP5-low versus CHMP5-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHMP5→partner) and Y-score (partner→CHMP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MRPS36P2 →	+0.307	+5.196	<.001	<.001	3	2
SKCM	PWRN4 →	+0.154	+5.159	<.001	.007	3	1
UCEC	TMPOP2 →	+0.308	+3.754	.004	<.001	3	1
UCEC	RN7SL134P →	+0.157	+2.751	<.001	.002	3	1
UCEC	ZNF850 →	+0.721	+2.537	<.001	.009	3	1
UCEC	SNHG30 →	+0.508	+2.606	.007	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,311 associations by consensus.

MRPS36P2 by CHMP5 expression — LUSC

Explore this box plot interactively →