CHMP5

Across TCGA patient cohorts, CHMP5 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHMP5-associated genes across cancer lineages are eEF2, INPP4B, and JNK2. Each is linked with CHMP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHMP5-to-partner and partner-to-CHMP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CHMP5-low versus CHMP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHMP5→partner) and Y-score (partner→CHMP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.462	+2.321	.010	.035	3	1
UCEC	INPP4B →	-0.354	-2.999	.029	.035	3	1
UCEC	JNK2 →	+0.207	+2.321	.038	.035	3	1
UCEC	MEK1 →	+0.506	+3.169	.005	.018	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.623	-2.308	.005	.036	3	1
UCEC	p70-S6K →	+0.198	+2.348	.040	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

eEF2 by CHMP5 expression — UCEC

Explore this box plot interactively →