CHMP5

Across TCGA cell cohorts, CHMP5 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,990 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CHMP5-associated GO terms across cancer lineages are DNA replication proofreading, Process utilizing autophagic mechanism, and Autophagy. Each is linked with CHMP5 in more than 9 cancer types. Because this analysis shows association rather than direction, both CHMP5-to-partner and partner-to-CHMP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication proofreading grouped by CHMP5-low versus CHMP5-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHMP5→partner) and Y-score (partner→CHMP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA replication proofreading →	-0.180	-0.685	<.001	<.001	3	10
SOFT_TISSUE	Process utilizing autophagic mechanism →	+0.058	+0.836	<.001	<.001	3	10
SOFT_TISSUE	Autophagy →	+0.058	+0.836	<.001	<.001	3	10
SOFT_TISSUE	Regulation of response to endoplasmic reticulum stress →	+0.053	+0.500	<.001	.006	3	9
BLOOD_Myeloma	Autophagosome assembly →	+0.082	+0.838	<.001	.002	3	9
BONE	snRNA catabolic process →	+0.109	+0.418	.001	.009	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,990 associations by consensus.

DNA replication proofreading by CHMP5 expression — BONE

Explore this box plot interactively →