CHMP4A

Across TCGA pan-cancer cohorts, CHMP4A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CHMP4A data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CHMP4A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CHMP4A expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where CHMP4A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.600	0.871	.008	18	view →
PDAC	DFS	Quartile	III,IV	0.767	0.313	.012	18	view →
LUAD	OS	Quartile	II,III,IV	0.430	0.885	.006	16	view →
CCRCC	DFS	Median	All	0.624	0.857	.010	6	view →
UCEC	DFS	Median	All	0.834	0.974	.003	4	view →
GBM	DFS	Tertile	All	0.691	0.876	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CHMP4A–LSCC (OS)

Open the LSCC breakdown →