CHMP4A

Across TCGA cell cohorts, CHMP4A RNA expression is significantly associated with the go_rna of many other GO terms, with 2,395 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CHMP4A-associated GO terms across cancer lineages are Vacuole organization, Protein linear polyubiquitination, and Establishment of vesicle localization. Each is linked with CHMP4A in more than 8 cancer types. Because this analysis shows association rather than direction, both CHMP4A-to-partner and partner-to-CHMP4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vacuole organization grouped by CHMP4A-low versus CHMP4A-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHMP4A→partner) and Y-score (partner→CHMP4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Vacuole organization →	+0.037	+0.516	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Protein linear polyubiquitination →	+0.165	+1.054	<.001	.002	3	8
LUNG_NSCLC_LUAD	Establishment of vesicle localization →	+0.032	+0.529	.001	.005	3	7
UPPER_AERODIGESTIVE_TRACT	DNA ADP-ribosylation →	+0.133	+0.896	<.001	.002	3	6
SOFT_TISSUE	Vesicle localization →	+0.031	+0.605	<.001	.003	3	6
SKIN	Thiamine metabolic process →	+0.816	+0.625	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,395 associations by consensus.

Vacuole organization by CHMP4A expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →