CHMP3

Across TCGA pan-cancer cohorts, CHMP3 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CHMP3 data layer compared with 27 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CHMP3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated CHMP3 expression acts as an unfavorable survival marker.

ACC, STAD, and READ are the cancer types where CHMP3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.010	0.667	<.001	45	view →
STAD	DFS	Median	All	0.196	0.658	.001	30	view →
READ	DFS	Median	All	0.182	0.819	.004	18	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CHMP3–ACC (DFS)

Open the ACC breakdown →