CHMP3

Across TCGA pan-cancer cohorts, CHMP3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CHMP3 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CHMP3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CHMP3 expression acts as an unfavorable survival marker.

LUAD, COAD, and CCRCC are the cancer types where CHMP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.442	0.804	.003	27	view →
COAD	DFS	Median	III,IV	0.891	1.000	.032	12	view →
CCRCC	OS	Median	III,IV	0.482	0.841	.002	5	view →
GBM	DFS	Tertile	All	0.242	0.468	.021	4	view →
LSCC	OS	Quartile	II,III,IV	0.856	1.000	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CHMP3–LUAD (DFS)

Open the LUAD breakdown →