CHMP3

Across TCGA patient cohorts, CHMP3 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHMP3-associated genes across cancer lineages are MEK1_p_S217_S221, PRAS40_pT246, and Tuberin. Each is linked with CHMP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHMP3-to-partner and partner-to-CHMP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1_p_S217_S221 grouped by CHMP3-low versus CHMP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHMP3→partner) and Y-score (partner→CHMP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1_p_S217_S221 →	+0.473	+2.999	<.001	.035	3	1
UCEC	PRAS40_pT246 →	+0.248	+2.183	.005	.035	3	1
UCEC	Tuberin →	+0.360	+3.321	.010	.010	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.473	+2.817	.034	.036	2	1
UCEC	MEK1 →	+0.483	+3.169	.011	.019	2	1
UCEC	eIF4E →	+0.247	+3.321	.025	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MEK1_p_S217_S221 by CHMP3 expression — UCEC

Explore this box plot interactively →