CHMP2B

Across TCGA cell cohorts, CHMP2B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,517 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CHMP2B-associated GO terms across cancer lineages are Vesicle fusion with vacuole, Multivesicular body-lysosome fusion, and ESCRT complex disassembly. Each is linked with CHMP2B in more than 14 cancer types. Because this analysis shows association rather than direction, both CHMP2B-to-partner and partner-to-CHMP2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vesicle fusion with vacuole grouped by CHMP2B-low versus CHMP2B-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHMP2B→partner) and Y-score (partner→CHMP2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Vesicle fusion with vacuole →	+0.142	+1.344	<.001	<.001	3	15
SOFT_TISSUE	Multivesicular body-lysosome fusion →	+0.147	+1.289	<.001	<.001	3	15
CNS	ESCRT complex disassembly →	+0.129	+1.021	<.001	<.001	3	15
CNS	ESCRT III complex disassembly →	+0.129	+1.021	<.001	<.001	3	15
LUNG_SCLC	Endosome to lysosome transport via multivesicular body sorting pathway →	+0.121	+0.741	<.001	<.001	3	14
STOMACH	Non-lytic viral release →	+0.124	+1.016	.001	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,517 associations by consensus.

Vesicle fusion with vacuole by CHMP2B expression — SOFT_TISSUE

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