CHMP1B

Across TCGA pan-cancer cohorts, CHMP1B mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CHMP1B data layer compared with 20 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CHMP1B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CHMP1B expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where CHMP1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	IV	0.861	0.162	.024	8	view →
HNSC	OS	Tertile	All	1.000	0.942	.022	7	view →
LSCC	DFS	Quartile	II,III,IV	0.928	0.614	.038	2	view →
GBM	DFS	Tertile	All	0.716	0.821	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CHMP1B–CCRCC (DFS)

Open the CCRCC breakdown →