CHMP1B

Across TCGA pan-cancer cohorts, CHMP1B mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CHMP1B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CHMP1B mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CHMP1B is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, PDAC, and LSCC are the cancer types where CHMP1B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHMP1B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.206	<.001	8	view →
PDAC	All	All	+0.322	<.001	6	view →
LSCC	Male	II,III,IV	+0.294	<.001	6	view →
HNSC	Male	All	−0.122	.019	3	view →
OV	All	All	+0.469	.010	2	view →
CCRCC	All	All	−0.117	.010	2	view →
LUAD	Female	III,IV	−0.515	.006	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CHMP1B–COAD

Open the COAD breakdown →