CHMP1A

Across TCGA patient cohorts, CHMP1A mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHMP1A-associated genes across cancer lineages are FOXO3a_pS318_S321, mTOR_pS2448, and Notch1. Each is linked with CHMP1A in more than 1 cancer types. Because this analysis shows association rather than direction, both CHMP1A-to-partner and partner-to-CHMP1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by CHMP1A-low versus CHMP1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHMP1A→partner) and Y-score (partner→CHMP1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.178	-2.999	.013	.035	3	1
UCEC	mTOR_pS2448 →	-0.205	-3.000	.017	.037	3	1
UCEC	Notch1 →	+0.165	+3.000	.042	.037	3	1
UCEC	PCNA →	+0.280	+3.000	.025	.036	3	1
UCEC	MEK1 →	+0.539	+3.000	.010	.037	1	2
UCEC	Annexin-1 →	+1.045	+3.000	<.001	.037	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

FOXO3a_pS318_S321 by CHMP1A expression — UCEC

Explore this box plot interactively →