Across TCGA patient cohorts, CHML protein abundance is significantly associated with the RNA expression of many other genes, with 7,338 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CHML-associated genes across cancer lineages are PAICS, EXO1, and DEPDC1B. Each is linked with CHML in more than 4 cancer types. Because this analysis shows association rather than direction, both CHML-to-partner and partner-to-CHML results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHML→partner) and Y-score (partner→CHML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PAICS →	+0.650	+0.428	<.001	<.001	3	5
BRCA	EXO1 →	+1.173	+0.479	<.001	<.001	3	5
UCEC	DEPDC1B →	+0.958	+0.275	<.001	.002	3	5
LSCC	LY9 →	-0.656	-0.314	.003	.001	3	4
HNSC	S1PR4 →	-0.761	-0.334	.003	.001	3	4
UCEC	TICRR →	+0.622	+0.215	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,338 associations by consensus.

Exploration

CHML survival (RNA) · tumor vs normal (RNA) · all CHML data types