Across TCGA patient cohorts, CHML mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHML-associated genes across cancer lineages are JNK_pT183_Y185, MEK1, and Rad50. Each is linked with CHML in more than 1 cancer types. Because this analysis shows association rather than direction, both CHML-to-partner and partner-to-CHML results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHML→partner) and Y-score (partner→CHML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.165	-1.986	.005	.003	3	2
UCEC	MEK1 →	+0.469	+2.392	<.001	<.001	3	2
UCEC	Rad50 →	-0.258	-1.662	.002	.011	3	2
UCEC	Annexin-1 →	+0.631	+2.827	<.001	.001	3	2
UCEC	ATM →	-0.549	-2.700	<.001	.006	3	2
UCEC	14-3-3_beta →	-0.117	-2.880	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

CHML survival (RNA) · tumor vs normal (RNA) · all CHML data types