Across TCGA cell cohorts, CHML mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CHML-associated genes across cancer lineages are CENPVL3, KLF18, and HOXB1. Each is linked with CHML in more than 1 cancer types. Because this analysis shows association rather than direction, both CHML-to-partner and partner-to-CHML results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHML→partner) and Y-score (partner→CHML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CENPVL3 →	+0.703	+4.906	<.001	.006	3	1
LARGE_INTESTINE	KLF18 →	+0.007	+3.345	<.001	.007	3	1
BLOOD_Lymphoma	HOXB1 →	+0.012	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	TSPY3 →	+0.027	+5.209	<.001	.005	3	1
LUNG_NSCLC_LUAD	KCNA1 →	+0.074	+3.760	<.001	.008	3	1
LUNG_NSCLC_LUAD	NEUROD4 →	+0.083	+4.215	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

CHML survival (RNA) · tumor vs normal (RNA) · all CHML data types