Across TCGA patient cohorts, CHM RNA expression is significantly associated with the protein abundance of many other proteins, with 10,644 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CHM-associated proteins across cancer lineages are CUL4B, SPCS3, and ARL3. Each is linked with CHM in more than 4 cancer types. Because this analysis shows association rather than direction, both CHM-to-partner and partner-to-CHM results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CHM→partner) and Y-score (partner→CHM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CUL4B →	+0.262	+0.497	<.001	<.001	3	5
PDAC	SPCS3 →	-0.468	-0.298	<.001	<.001	3	5
BRCA	ARL3 →	+0.529	+0.539	<.001	.001	3	4
LSCC	MAST3_S134 →	-0.515	-0.338	.002	<.001	3	4
BRCA	RPL7 →	-0.345	-0.655	<.001	<.001	3	4
BRCA	TCEAL1_S28 →	+0.656	+0.412	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,644 associations by consensus.

Exploration

CHM survival (RNA) · tumor vs normal (RNA) · all CHM data types