Across TCGA patient cohorts, CHM protein abundance is significantly associated with the RNA expression of many other genes, with 10,756 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CHM-associated genes across cancer lineages are LHFPL2, ZBTB12, and NCF2. Each is linked with CHM in more than 4 cancer types. Because this analysis shows association rather than direction, both CHM-to-partner and partner-to-CHM results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHM→partner) and Y-score (partner→CHM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LHFPL2 →	+0.590	+0.263	<.001	<.001	3	5
LSCC	ZBTB12 →	-0.609	-0.199	.003	.002	3	5
UCEC	NCF2 →	+1.061	+0.184	.001	.003	3	4
GBM	MED13L →	-0.403	-0.221	.001	.001	3	4
LUAD	TREM1 →	+1.059	+0.163	<.001	.001	3	4
LUAD	DUSP6 →	+0.855	+0.161	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,756 associations by consensus.

Exploration

CHM survival (RNA) · tumor vs normal (RNA) · all CHM data types