Across TCGA patient cohorts, CHM mutation is significantly associated with the RNA expression of many other genes, with 6,219 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHM-associated genes across cancer lineages are CENPVL1, DGKZ, and MTA2. Each is linked with CHM in more than 2 cancer types. Because this analysis shows association rather than direction, both CHM-to-partner and partner-to-CHM results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHM→partner) and Y-score (partner→CHM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CENPVL1 →	+0.018	+4.105	<.001	.007	3	3
UCEC	DGKZ →	+0.234	+2.747	.005	<.001	3	2
UCEC	MTA2 →	+0.444	+1.990	<.001	<.001	3	2
UCEC	INCENP →	+0.543	+1.471	<.001	<.001	3	2
UCEC	CPSF7 →	+0.407	+1.958	<.001	<.001	3	2
UCEC	DSN1 →	+0.431	+2.271	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,219 associations by consensus.

Exploration

CHM survival (RNA) · tumor vs normal (RNA) · all CHM data types