CHM

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, CHM mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHM-associated genes across cancer lineages are 4E-BP1, p27_pT157, and p27_pT198. Each is linked with CHM in more than 2 cancer types. Because this analysis shows association rather than direction, both CHM-to-partner and partner-to-CHM results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHM→partner) and Y-score (partner→CHM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCEC4E-BP1 →+0.334+3.392<.001<.00133
UCECp27_pT157 →-0.034-1.162.033.02532
UCECp27_pT198 →+0.064+1.000.031.03332
UCECp38-MAPK_pT180_Y182 →-0.302-1.152.015.04832
UCECRab11 →-0.138-1.494<.001.00132
UCECTuberin_pT1462 →+0.191+1.424.002.00532
Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Exploration