CHL1

Across TCGA patient cohorts, CHL1 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,718 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CHL1-associated proteins across cancer lineages are CHL1_S1127, SGCD, and TRIOBP. Each is linked with CHL1 in more than 6 cancer types. Because this analysis shows association rather than direction, both CHL1-to-partner and partner-to-CHL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHL1 versus CHL1_S1127 in LSCC, with a Pearson correlation of 0.80.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CHL1→partner) and Y-score (partner→CHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CHL1_S1127 →	+1.574	+1.864	<.001	<.001	3	7
COAD	SGCD →	+0.628	+0.759	<.001	<.001	3	5
GBM	TRIOBP →	+0.340	+1.043	<.001	.008	3	5
COAD	DPYSL3 →	+0.741	+0.702	<.001	<.001	3	5
BRCA	FERMT2 →	+0.649	+0.860	<.001	<.001	3	5
COAD	ZCCHC24 →	+0.567	+0.938	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,718 associations by consensus.

CHL1 vs CHL1_S1127 — LSCC

Explore this scatter interactively →