CHL1

Across TCGA patient cohorts, CHL1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,672 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CHL1-associated genes across cancer lineages are CHL1-AS2, CHL1-AS1, and RPS8P6. Each is linked with CHL1 in more than 6 cancer types. Because this analysis shows association rather than direction, both CHL1-to-partner and partner-to-CHL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHL1 versus CHL1-AS2 in GBM, with a Pearson correlation of 0.63.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHL1→partner) and Y-score (partner→CHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CHL1-AS2 →	+0.564	+0.524	<.001	<.001	3	7
LUAD	CHL1-AS1 →	+1.307	+0.695	<.001	<.001	3	7
LUAD	RPS8P6 →	+0.941	+0.713	<.001	<.001	3	5
GBM	RNU6-1194P →	+2.194	+0.848	<.001	<.001	3	5
LSCC	DARS2 →	-0.470	-0.452	<.001	<.001	3	5
BRCA	MEDAG →	+1.238	+0.643	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,672 associations by consensus.

CHL1 vs CHL1-AS2 — GBM

Explore this scatter interactively →