CHL1

Across TCGA patient cohorts, CHL1 protein abundance is significantly associated with the protein abundance of many other proteins, with 23,149 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CHL1-associated proteins across cancer lineages are RANBP2, CCAR1, and RRP12. Each is linked with CHL1 in more than 6 cancer types. Because this analysis shows association rather than direction, both CHL1-to-partner and partner-to-CHL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHL1 versus RANBP2 in COAD, with a Pearson correlation of -0.55.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CHL1→partner) and Y-score (partner→CHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RANBP2 →	-0.223	-0.508	<.001	<.001	3	7
GBM	CCAR1 →	-0.184	-0.403	<.001	<.001	3	6
BRCA	RRP12 →	-0.579	-0.850	<.001	<.001	3	6
LSCC	CHL1_S1127 →	+1.475	+1.025	<.001	<.001	3	6
GBM	CTNNBL1 →	-0.227	-0.473	<.001	<.001	3	6
COAD	HSP90AB1 →	-0.265	-0.385	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 23,149 associations by consensus.

CHL1 vs RANBP2 — COAD

Explore this scatter interactively →