CHL1

Across TCGA patient cohorts, CHL1 mutation is significantly associated with the RNA expression of many other genes, with 6,650 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHL1-associated genes across cancer lineages are NDC80, POLE2, and CDKN3. Each is linked with CHL1 in more than 5 cancer types. Because this analysis shows association rather than direction, both CHL1-to-partner and partner-to-CHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDC80 grouped by CHL1-low versus CHL1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHL1→partner) and Y-score (partner→CHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NDC80 →	+0.617	+1.333	.002	.008	3	6
STAD	POLE2 →	+0.511	+3.182	.009	.009	3	5
UCEC	CDKN3 →	+0.547	+1.364	<.001	<.001	3	5
UCEC	NUP88 →	+0.251	+1.353	.002	<.001	3	5
SKCM	NCAPG →	+0.524	+1.432	<.001	.004	3	5
UCEC	FBXO5 →	+0.468	+1.353	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,650 associations by consensus.

NDC80 by CHL1 expression — LUAD

Explore this box plot interactively →