CHL1

Across TCGA cell cohorts, CHL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,506 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CHL1-associated GO terms across cancer lineages are Phosphatidylinositol biosynthetic process, Regulation of coagulation, and Regulation of TORC1 signaling. Each is linked with CHL1 in more than 4 cancer types. Because this analysis shows association rather than direction, both CHL1-to-partner and partner-to-CHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Phosphatidylinositol biosynthetic process grouped by CHL1-low versus CHL1-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHL1→partner) and Y-score (partner→CHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Phosphatidylinositol biosynthetic process →	+0.035	+2.397	.008	<.001	3	5
LUNG_SCLC	Regulation of coagulation →	-0.148	-1.951	<.001	.001	3	5
LUNG_SCLC	Regulation of TORC1 signaling →	+0.044	+2.224	<.001	<.001	3	5
SKIN	Cardiolipin metabolic process →	+0.073	+1.855	<.001	<.001	3	5
LUNG_SCLC	Negative regulation of TORC1 signaling →	+0.052	+2.320	.002	<.001	3	5
BLOOD_Lymphoma	Regulation of endopeptidase activity →	-0.204	-0.908	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,506 associations by consensus.

Phosphatidylinositol biosynthetic process by CHL1 expression — SKIN

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