CHL1

Across TCGA cell cohorts, CHL1 mutation is significantly associated with the RNA expression of many other genes, with 589 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHL1-associated genes across cancer lineages are MRGPRE, GAGE12F, and GAGE2E. Each is linked with CHL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHL1-to-partner and partner-to-CHL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRGPRE grouped by CHL1-low versus CHL1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHL1→partner) and Y-score (partner→CHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MRGPRE →	+0.024	+4.832	.001	<.001	3	3
CNS	GAGE12F →	+1.032	+2.350	<.001	.005	3	2
SOFT_TISSUE	GAGE2E →	+3.098	+4.459	<.001	.001	3	2
URINARY_TRACT	IL3 →	+0.020	+4.087	<.001	.009	3	2
URINARY_TRACT	CFAP97D2 →	+0.032	+4.087	<.001	.009	3	2
LARGE_INTESTINE	GRSF1 →	+0.713	+3.212	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 589 associations by consensus.

MRGPRE by CHL1 expression — SOFT_TISSUE

Explore this box plot interactively →