Across TCGA pan-cancer cohorts, CHL1-AS2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CHL1-AS2’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CHL1-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types CHL1-AS2 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.
KIRC, COAD, and STAD are the cancer types where CHL1-AS2 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHL1-AS2 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.