CHL1-AS1

Across TCGA pan-cancer cohorts, CHL1-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CHL1-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CHL1-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CHL1-AS1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and UVM show a favorable association.

ACC, UCEC, and ESCA are the cancer types where CHL1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	III,IV	0.149	0.565	<.001	132	view →
UCEC	DFS	Quartile	III,IV	0.276	0.666	.001	96	view →
ESCA	DFS	Tertile	III,IV	0.644	0.299	.002	47	view →
UVM	OS	Median	All	0.759	0.450	.006	40	view →
SKCM	OS	Tertile	III,IV	0.480	0.175	.001	37	view →
CESC	DFS	Tertile	II,III,IV	0.337	0.594	.015	30	view →
THCA	OS	Tertile	II,III,IV	0.695	0.989	<.001	28	view →
LGG	OS	Median	All	0.749	0.864	<.001	28	view →
PAAD	OS	Median	All	0.641	0.392	.007	23	view →
OV	DFS	Median	IV	0.353	0.564	.012	22	view →
CHOL	DFS	Tertile	II,III,IV	0.792	0.135	.020	21	view →
TGCT	DFS	Tertile	All	0.378	0.739	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CHL1-AS1–ACC (DFS)

Open the ACC breakdown →