CHKB

Across TCGA pan-cancer cohorts, CHKB mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CHKB data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CHKB mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CHKB expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

COAD, CCRCC, and LSCC are the cancer types where CHKB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.908	1.000	.007	60	view →
CCRCC	DFS	Median	III,IV	0.786	0.414	.005	36	view →
LSCC	DFS	Median	II,III,IV	0.540	0.850	.009	21	view →
LUAD	OS	Median	III,IV	0.330	0.869	.006	18	view →
HNSC	DFS	Median	IV	0.889	0.407	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CHKB–COAD (DFS)

Open the COAD breakdown →